IQ-1S

1. IQ-1S inhibits JNK signalling in rats.

   “suppression of the JNK signaling pathway activity during active progression of AMD signs in OXYS rats”

   Animalsduring active progression of AMD signs in OXYS ratsretina

   Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S)

   Cells·13 Jun 2025

2. IQ-1S inhibits JNK signalling in rats.

   “the selective JNK3 inhibitor IQ-1S and its ability to suppress the development of neurodegenerative processes in OXYS rats were associated with a decrease in the phosphorylation levels of JNK3, c-Jun, APP, and Tau”

   Animalsin senescence-accelerated OXYS ratshippocampus

   JNK Signaling Pathway Activity Alterations in the Rat Hippocampus: Effect of Age, Alzheimer's Disease-Like Pathology Development, and the JNK Inhibitor IQ-1S

   Biochemistry. Biokhimiia·1 Feb 2025

More on JNK signalling

1. IQ-1S prevents synaptic degeneration in rats.

   “prevention of the destructive changes in retinal synapses”

   Animalsin OXYS ratsretinal synapses

   Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S)

   Cells·13 Jun 2025

1. IQ-1S decreases retinal neurodegeneration in rats.

   “selective JNK3 inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S) can suppress neurodegenerative changes in the OXYS rat retina”

   Animalsin OXYS ratsretina

   Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S)

   Cells·13 Jun 2025