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Intermedin

Intervention

1 paper3 findings

PubChem 114843ChEBI 5941

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Government of Jiangsu Province and 5 more
  • Animals1

Outcomes

3

NAD+

upin mouse cells1

1 study

  1. Intermedin increases NAD+ in mouse cells.

    “IMD increased intracellular NAD+ by activating nicotinamide phosphoribosyl transferase (NAMPT), followed by enhancing poly (ADP-ribose) polymerase-1 (PARP1) activity.”

    Cellsin mouse VSMCs

    Intermedin Inhibits DNA Damage-Promoted Senescent Phenotype Transition of Vascular Smooth Muscle Cells in Aorta by Activating NAMPT/PARP1 in Mice

    Pharmaceuticals (Basel, Switzerland)7 Oct 2025

More on NAD+

DNA damage response

downin mouse cells1

1 study

  1. Intermedin inhibits DNA damage response in mouse cells.

    “IMD alleviates DNA damage partially by activating NAMPT/PARP1, thereby inhibiting the senescent phenotype transition of VSMCs of aorta”

    Cellsin Ang II-treated mouse VSMCsaorta

    Intermedin Inhibits DNA Damage-Promoted Senescent Phenotype Transition of Vascular Smooth Muscle Cells in Aorta by Activating NAMPT/PARP1 in Mice

    Pharmaceuticals (Basel, Switzerland)7 Oct 2025

More on DNA damage response

Cellular senescence

downin mouse cells1

1 study

  1. Intermedin decreases cellular senescence in mouse cells.

    “Ang II-induced increases in senescence-associated proteins and DNA damage markers could be mitigated by the administration of IMD in vitro.”

    Cellsin Ang II-treated mouse VSMCsaorta

    Intermedin Inhibits DNA Damage-Promoted Senescent Phenotype Transition of Vascular Smooth Muscle Cells in Aorta by Activating NAMPT/PARP1 in Mice

    Pharmaceuticals (Basel, Switzerland)7 Oct 2025

More on Cellular senescence

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