Intensive lifestyle intervention
Intervention2 papers1 finding
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Human trial2
Outcomes
1IL-6
downin humans1
1 study
IL-6
downin humans1
Intensive lifestyle intervention decreases IL-6 in humans (-28.7% vs -11.8%).
Human trialcompared with diabetes support and education in T2D and overweight/obesitytargeting weight loss1-year
Residual Inflammatory Risk of Heart Failure and Atherosclerotic CVD in Diabetes: Look AHEAD Ancillary Study · JACC. Heart failure · 2 Sep 2026