Injectable crispr-based gene-editing microspheres

InterventionPreclinical

1 paper2 findings

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

2

Vascularization

upin mice1

1 study
  1. Injectable crispr-based gene-editing microspheres improve vascularization in mice (3.1 times faster).

    “promoted vascularization 3.1 times faster (CD31+ staining) compared to controls”

    Animalscritical-sized bone defectsbone

    Injectable CRISPRa-microspheres for targeted A20 activation rescue age-related osteogenic impairment via senescence mitigation

    Biomaterials5 Nov 2025

Defect healing

upin mice1+80% defect healing

1 study
  1. Injectable crispr-based gene-editing microspheres improve defect healing in mice (~80% defect healing).

    “achieving approximately 80 % defect healing in aged bone defect models”

    Animalscritical-sized bone defectsbone

    Injectable CRISPRa-microspheres for targeted A20 activation rescue age-related osteogenic impairment via senescence mitigation

    Biomaterials5 Nov 2025

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