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Induced pluripotent stem cell-derived small extracellular vesicles

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 3 more
  • Animals1

Outcomes

2

Cellular senescence

downin mice1

1 study

  1. Induced pluripotent stem cell-derived small extracellular vesicles decrease cellular senescence in mice.

    “In vivo, iPSC-sEVs alleviated cognitive deficits and H-NSC senescence after TBI.”

    Animalsin a mouse model of TBI

    Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence to Promote Cognitive Recovery after Traumatic Brain Injury

    ACS nano23 Oct 2025

More on Cellular senescence

Cognitive function

upin mice1

1 study

  1. Induced pluripotent stem cell-derived small extracellular vesicles improve cognitive function in mice.

    “In vivo, iPSC-sEVs alleviated cognitive deficits and H-NSC senescence after TBI.”

    Animalsin a mouse model of TBI

    Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence to Promote Cognitive Recovery after Traumatic Brain Injury

    ACS nano23 Oct 2025

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