Indomethacin

1. Indomethacin decreases flow-mediated dilation in humans.

   “Indo eliminated FMD in children and reduced FMD in younger adults.”

   Human trialex vivo arteriolescoronary or adipose arterioles

   Transition in the mechanism of flow-mediated dilation with aging and development of coronary artery disease

   Basic research in cardiology·19 Dec 2016

1. Indomethacin decreases IL-23 in mouse cells.

   “up-regulation of IL-23 expression by aged DC was blocked by indomethacin that prevents PGE2 production”

   Cellsin aged bone marrow-derived dendritic cellsbone marrow

   Prostaglandin E2-dependent IL-23 production in aged murine dendritic cells

   Experimental gerontology·1 Jul 2010

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1. Indomethacin inhibits angiogenesis in mice.

   “reduction in vascularity, indicating that the beneficial effects of indo were due to multiple mechanisms, including improved immune response and reduced angiogenesis.”

   Animalsoralmammary tumorup to 25 months of agefemales

   Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice

   International journal of cancer·4 Nov 1997

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1. Indomethacin extends lifespan in mice.

   “the lifespan of mice bearing multiple tumors was significantly prolonged by therapy.”

   Animalsmice bearing multiple tumorsoralup to 25 months of agefemales

   Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice

   International journal of cancer·4 Nov 1997

1. Indomethacin increases spontaneous regression of primary tumors in mice (2-fold (53% vs 26%)).

   “Spontaneous regression of primary tumors (26% in controls) increased 2-fold (53%) with indo therapy.”

   Animalsoralup to 25 months of agefemales

   Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice

   International journal of cancer·4 Nov 1997

1. Indomethacin decreases erythroleukemia cell count in mice.

   “indomethacin- and/or rIL-2 treated leukemic infant and young adult mice have significantly lower numbers of erythroleukemia cells in both the spleen and bone marrow”

   Animalserythroleukemia-bearing micespleen and bone marrow10 days

   Effect on leukemia cell numbers of in vivo administration of immunotherapeutic agents is age-dependent

   Oncology·1 Jan 1996

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1. Indomethacin lowers the risk of lung metastases in mice (2-fold reduction).

   “There was also a 2-fold reduction in the incidence of lung metastases in mice bearing detectable primary tumors”

   Animalsmice bearing detectable primary tumorsoralup to 25 months of agefemales

   Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice

   International journal of cancer·4 Nov 1997

More on Lung metastases