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Increased substrate stiffness

Exposure

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Johns Hopkins University and 3 more
  • Cells1

Outcomes

1

p21WAF1/Cip1

upin human cells1

1 study

  1. Increased substrate stiffness increases p21WAF1/Cip1 in human cells.

    “when cells are transferred from soft to stiff substrates, senescent cells recover an elevated expression of p21WAF1/CIP1 and p16INK4a”

    Cellssenescent dermal fibroblasts transferred from soft to stiff substratesskin

    Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

    bioRxiv : the preprint server for biology19 Feb 2024Preprint

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