AgingResearch.NewsJoin free

Decreased substrate stiffness

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Johns Hopkins University and 3 more
  • Cells1

Outcomes

3

p16INK4a

downin human cells1

1 study

  1. Decreased substrate stiffness decreases p16INK4a in human cells.

    “senescence-induced dermal fibroblasts on soft substrates (0.5 kPa) do not express p21WAF1/CIP1 and p16INK4a at comparable levels to induced cells on stiff substrates (4GPa)”

    Cellsafter exposure to senescence inducersskin

    Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

    bioRxiv : the preprint server for biology19 Feb 2024Preprint

More on p16INK4a

p21WAF1/Cip1

downin human cells1

1 study

  1. Decreased substrate stiffness decreases p21WAF1/Cip1 in human cells.

    “senescence-induced dermal fibroblasts on soft substrates (0.5 kPa) do not express p21WAF1/CIP1 and p16INK4a at comparable levels to induced cells on stiff substrates (4GPa)”

    Cellsafter exposure to senescence inducersskin

    Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

    bioRxiv : the preprint server for biology19 Feb 2024Preprint

More on p21WAF1/Cip1

Cell-cycle arrest

upin human cells1

1 study

  1. Decreased substrate stiffness increases cell-cycle arrest in human cells.

    “decreased substrate stiffness accelerates senescence-associated cell-cycle arrest”

    Cellsafter exposure to senescence inducersskin

    Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

    bioRxiv : the preprint server for biology19 Feb 2024Preprint

Latest

Related