IGFBP-3 neutralizing antibody

1 paper2 findings

1 lab in 1 country

Funder: National Science and Technology Council

Animals1

Outcomes

2

AGE–RAGE signalling

downin mice1

1 study

IGFBP-3 neutralizing antibody decreases AGE–RAGE signalling in mice.
“AGE accumulation and IGFBP-3 expression were reciprocally attenuated by both interventions”
Animalsin naturally aged micekidneymales
Functional interaction between advanced glycation end-products and IGFBP-3 contributes to renal pathology in aging-associated chronic kidney disease
Tissue & cell15 May 2026

More on AGE–RAGE signalling

Renal dysfunction

downin mice1

1 study

IGFBP-3 neutralizing antibody decreases renal dysfunction in mice.
“Pharmacological inhibition of AGE formation or IGFBP-3 neutralization significantly ameliorated these age-associated impairments.”
Animalsin naturally aged micekidneymales
Functional interaction between advanced glycation end-products and IGFBP-3 contributes to renal pathology in aging-associated chronic kidney disease
Tissue & cell15 May 2026

Latest

1 in 12 months

Tissue & Cell20 May

Functional interaction between advanced glycation end-products and IGFBP-3 contributes to renal pathology in aging-associated chronic kidney disease

Experiments in miceChronic kidney disease