Hypoxia-conditioned wharton's jelly mesenchymal stromal cell exosomes

1. Hypoxia-conditioned wharton's jelly mesenchymal stromal cell exosomes decrease senescence-associated beta-galactosidase in human cells.

   “the 1:30 and 1:10 dilution significantly reduced β-galactosidase activity in senescent fibroblasts with the 1/10 dilution showing the strongest reduction (p = 0.0010)”

   Cellsin senescent fibroblasts72 h

   Cryopreserved exosomes derived from hypoxic Wharton's jelly mesenchymal stromal cells enhance fibroblast proliferation, upregulate COL1A2 expression, and mitigate senescence

   Frontiers in medicine·17 Dec 2025

More on Senescence-associated beta-galactosidase

1. Hypoxia-conditioned wharton's jelly mesenchymal stromal cell exosomes increase COL1A2 in human cells.

   “COL1A2 expression was significantly upregulated at the 1:30 (p = 0.0418), and 1:10 dilutions (p = 0.0002)”

   Cells72 h

   Cryopreserved exosomes derived from hypoxic Wharton's jelly mesenchymal stromal cells enhance fibroblast proliferation, upregulate COL1A2 expression, and mitigate senescence

   Frontiers in medicine·17 Dec 2025

More on COL1A2

1. Hypoxia-conditioned wharton's jelly mesenchymal stromal cell exosomes increase fibroblast proliferation in human cells.

   “Exosome treatment promoted fibroblast proliferation in a dose-dependent manner, with significant effects observed at the 1:30 and 1:10 dilutions (p < 0.05 and p < 0.01, respectively).”

   Cells72 h

   Cryopreserved exosomes derived from hypoxic Wharton's jelly mesenchymal stromal cells enhance fibroblast proliferation, upregulate COL1A2 expression, and mitigate senescence

   Frontiers in medicine·17 Dec 2025