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Hydrostatic pressure

Intervention

1 paper studies it5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 2 more
  • Animals1

Outcomes

5

Cartilage regeneration

upin animals1

1 study

  1. Hydrostatic pressure improves cartilage regeneration.

    “in vitro regenerated cartilage in the HP group further developed after implantation and formed homogeneous and mature cartilage close to the native one”

    Animalsafter in vitro regeneration under hydrostatic pressure

    In vitro Cartilage Regeneration Regulated by a Hydrostatic Pressure Bioreactor Based on Hybrid Photocrosslinkable Hydrogels

    Frontiers in bioengineering and biotechnology

Apoptosis

downin cells1

1 study

  1. Hydrostatic pressure inhibits apoptosis in cells.

    “HP regulated in vitro cartilage regeneration primarily by inhibiting cell senescence and apoptosis”

    Cellsin chondrocyte-laden hybrid photocrosslinkable hydrogels5 MPa8 weeks

    In vitro Cartilage Regeneration Regulated by a Hydrostatic Pressure Bioreactor Based on Hybrid Photocrosslinkable Hydrogels

    Frontiers in bioengineering and biotechnology

More on Apoptosis

Cellular senescence

downin cells1

1 study

  1. Hydrostatic pressure inhibits cellular senescence in cells.

    “HP regulated in vitro cartilage regeneration primarily by inhibiting cell senescence and apoptosis, promoting ECM synthesis, suppressing ECM catabolism, and ECM structure remodeling.”

    Cellsin chondrocyte-laden hybrid photocrosslinkable hydrogels5 MPa8 weeks

    In vitro Cartilage Regeneration Regulated by a Hydrostatic Pressure Bioreactor Based on Hybrid Photocrosslinkable Hydrogels

    Frontiers in bioengineering and biotechnology

More on Cellular senescence

Extracellular matrix remodeling

upin cells1

1 study

  1. Hydrostatic pressure increases extracellular matrix remodeling in cells.

    “significantly enhanced cell viability, proliferation, and extracellular matrix (ECM) deposition by improving nutrient transportation”

    Cellsin chondrocyte-laden 3% wt% hybrid photocrosslinkable hydrogels5 MPa8 weeks

    In vitro Cartilage Regeneration Regulated by a Hydrostatic Pressure Bioreactor Based on Hybrid Photocrosslinkable Hydrogels

    Frontiers in bioengineering and biotechnology

More on Extracellular matrix remodeling

Cell viability

upin cells1

1 study

  1. Hydrostatic pressure improves cell viability in cells.

    “HP completely reversed the negative influences of HPC hydrogels at 3% wt%, significantly enhanced cell viability, proliferation, and extracellular matrix (ECM) deposition”

    Cellsin chondrocyte-laden 3% wt% hybrid photocrosslinkable hydrogels5 MPa8 weeks

    In vitro Cartilage Regeneration Regulated by a Hydrostatic Pressure Bioreactor Based on Hybrid Photocrosslinkable Hydrogels

    Frontiers in bioengineering and biotechnology

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