Human umbilical cord blood mononuclear cells

Intervention

5 papers11 findings

4 independent labs in 1 country

Animals5

Outcomes

Lifespan

upin mice5

5 studies

Human umbilical cord blood mononuclear cells extend lifespan in mice.
“transplantation of HUCB cells either before or after the development of tumor significantly increased the life span compared to that of control mice.”
Animals200 x10(6) cellsn = 20
Administration of human umbilical cord blood cells delays the onset of prostate cancer and increases the lifespan of the TRAMP mouse
Cancer letters8 Jan 2006
Human umbilical cord blood mononuclear cells extend lifespan in mice.
“mice treated with HUCB cells significantly lowered their blood glucose levels and increased their lifespan”
Animalsin nonobese diabetic micemononuclear cells
Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice
Biochemical and biophysical research communications17 Dec 2004
Human umbilical cord blood mononuclear cells extend lifespan in mice.
“we were able to ameliorate the disease and improved the life span.”
Animalstype 1 diabetesmononuclear cells
NOD/LtJ type I diabetes in mice and the effect of stem cells (Berashis) derived from human umbilical cord blood
Journal of medicine1 Jan 2002
Human umbilical cord blood mononuclear cells extend lifespan in mice (from 88 days to 97.8 and 103.4 days).
“increase the life span of B6CBA-TgN(Hdexon1)62Gpb mice (Huntington disease) from an average of 88 days to 97.8 and 103.4 days respectively”
AnimalsHuntington disease71-74 x 10(6) and 100-105 x 10(6)
Human umbilical cord blood cells ameliorate Huntington's disease in transgenic mice
Journal of medicine1 Jan 2001
Human umbilical cord blood mononuclear cells extend lifespan in mice (162 days vs 123.5 days).
“The average life of the controls was 123.5 days while that of mice receiving the larger megadose of cells was 162 days.”
Animalsafter 800 cGy of irradiation in SOD1 micemononuclear cells from pooled human umbilical cord blood70.2-73.3 x 10(6) cells
The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice
Journal of medicine1 Jan 2000

Prostate cancer

downin mice1

1 study

Human umbilical cord blood mononuclear cells prevent prostate cancer in mice (238+/-38 vs 311+/-40 days, P<0.001).
“the control mice developed the tumor much earlier than the treated mice (control vs treated: 238+/-38 vs 311+/-40 days; P<0.001).”
Animalsretro-orbital intravenous administration before tumor development200 x10(6) cellsn = 20
Administration of human umbilical cord blood cells delays the onset of prostate cancer and increases the lifespan of the TRAMP mouse
Cancer letters8 Jan 2006