Human cytomegalovirus
4 papers11 findings
- 2 independent labs in 2 countries
- Funders: McMaster University and 4 more
- Humans1
Outcomes
7LMNB1
downin human cells1
1 study
LMNB1
downin human cells1
Human cytomegalovirus decreases LMNB1 in human cells.
“only infected RPTECs show downregulation of LAMINB1 and KI67 mRNAs, and enhanced secretion of IL-6 and IL-8”
Cellsin RPTECs
Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells
Communications biologyMar 8, 2024
Senescence-associated secretory phenotype (SASP)
upin human cells1
1 study
Senescence-associated secretory phenotype (SASP)
upin human cells1
Human cytomegalovirus induces senescence-associated secretory phenotype (SASP) in human cells.
“RPTECs are fully permissive for HCMV replication, which endows them with an inflammatory gene signature resembling the senescence-associated secretory phenotype (SASP)”
Cellsin RPTECs
Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells
Communications biologyMar 8, 2024
Inflammation
upin humans1
1 study
Inflammation
upin humans1
Human cytomegalovirus induces inflammation in humans.
“We explore the mechanisms through which CMV can impact both the composition and functionality of immune cell populations and induce shifts in inflammatory profiles with aging.”
Reviewchronic infection
International journal of molecular sciencesJan 6, 2024
COVID-19
no changein humans1
1 study
COVID-19
no changein humans1
Human cytomegalovirus has no effect on COVID-19 in humans.
“CMV seropositive individuals did not have a higher incidence of COVID-19”
Humans
medRxivMay 28, 2022Preprint
Immune response
no changein humans1
1 study
Immune response
no changein humans1
Human cytomegalovirus has no effect on immune response in humans.
“however, this did not impact Spike-specific CD4 + T cell memory recall responses.”
Humansafter SARS-CoV-2 mRNA vaccination
medRxivMay 28, 2022Preprint
TEMRA cell count
upin humans1
1 study
TEMRA cell count
upin humans1
Human cytomegalovirus increases TEMRA cell count in humans.
“CMV seropositivity altered T cell expression of senescence-associated markers and increased T EMRA cell numbers”
Humans
medRxivMay 28, 2022Preprint
anti-SARS-CoV-2 IgG
no changein humans1
1 study
anti-SARS-CoV-2 IgG
no changein humans1
Human cytomegalovirus has no effect on anti-SARS-CoV-2 IgG in humans.
“CMV serostatus did not affect anti-Spike and anti-RBD IgG antibody levels, nor neutralization capacity against wildtype or beta variants of SARS-CoV-2 several months after vaccination.”
Humansafter 2 and 3 SARS-CoV-2 mRNA vaccine doses
medRxivMay 28, 2022Preprint
Associations
4Immune system
upin humans1
1 study
Immune system
upin humans1
Human cytomegalovirus is associated with immune system in humans.
“Latent CMV infection exerts a profound influence on the aging immune system, potentially contributing to age-related diseases.”
Reviewlatent infection
International journal of molecular sciencesJan 6, 2024
Cellular senescence
upin reviews1
1 study
Cellular senescence
upin reviews1
Human cytomegalovirus is associated with cellular senescence.
“Human cytomegalovirus (HCMV) is a ubiquitous pathogen that plays an important role in the senescence process.”
Review
DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
Virology journalNov 1, 2023
Depression
upin humans1
1 study
Depression
upin humans1
Human cytomegalovirus is associated with depression in humans.
“Ultimately, we focus on one other deleterious effect of HCMV, namely the emerging literature suggesting that HCMV plays a pathophysiological role in psychiatric illness, particularly depression and schizophrenia.”
Reviewinfection
Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health
Current topics in behavioral neurosciencesJul 25, 2022
Epigenetic clock
upin humans1
1 study
Epigenetic clock
upin humans1
Human cytomegalovirus is associated with epigenetic clock in humans.
“HCMV infection has been linked with a host of deleterious effects including accelerated immune aging (premature mortality, increased expression of immunosenescence-linked markers, telomere shortening, speeding-up of epigenetic "clocks")”
Reviewinfection
Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health
Current topics in behavioral neurosciencesJul 25, 2022