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Human amnion-derived mesenchymal stem cells

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Government of Jiangsu Province and 3 more
  • Animals1

Outcomes

4

SOD2

upin mice1

1 study

  1. Human amnion-derived mesenchymal stem cells increase SOD2 in mice.

    “meanwhile increased Sod2 expression was also observed”

    Animalsage-related diminished ovarian reserveovary

    Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

    Stem cell research & therapy2 Jun 2021

More on SOD2

AMPK signalling

upin mice1

1 study

  1. Human amnion-derived mesenchymal stem cells increase AMPK signalling in mice.

    “expression level of Ampk and the ratio of phosphorylated FoxO3a to total FoxO3a both were significantly increased”

    Animalsage-related diminished ovarian reserveovary

    Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

    Stem cell research & therapy2 Jun 2021

More on AMPK signalling

Apoptosis of granulosa and stromal cells

downin mice1

1 study

  1. Human amnion-derived mesenchymal stem cells decrease apoptosis of granulosa and stromal cells in mice.

    “the apoptosis of granulosa and stromal cells in the ovaries was significantly repressed”

    Animalsage-related diminished ovarian reserveovary

    Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

    Stem cell research & therapy2 Jun 2021

More on Apoptosis of granulosa and stromal cells

Ovarian function

upin mice1

1 study

  1. Human amnion-derived mesenchymal stem cells improve ovarian function in mice.

    “after hAMSC transplantation, the ovarian function in AR-DOR mice was significantly improved”

    Animalsage-related diminished ovarian reserveovary

    Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

    Stem cell research & therapy2 Jun 2021

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