HM17321

Intervention1 paper4 findings

Animals1

Outcomes

4

Muscle atrophy

downin mice1Very low certainty

1 study

HM17321 protects against muscle atrophy in mice.
Animalsin a dexamethasone-induced muscle atrophy modelskeletal muscle
HM17321, a CRFR2 Selective UCN2 Analog, Prevents Muscle Loss and Functional Decline in Sarcopenic Mice · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Muscle atrophy →

Grip strength

upin mice1Very low certainty

1 study

HM17321 improves grip strength in mice.
Animalsin SAMP8 mice4 monthsmales
HM17321, a CRFR2 Selective UCN2 Analog, Prevents Muscle Loss and Functional Decline in Sarcopenic Mice · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Grip strength →

Fat mass

downin mice1−23%Very low certainty

1 study

HM17321 decreases fat mass in mice (up to -23.0%).
Animalsin SAMP8 mice vs vehicle4 monthsmales
HM17321, a CRFR2 Selective UCN2 Analog, Prevents Muscle Loss and Functional Decline in Sarcopenic Mice · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Lean mass

upin mice1+7.9%Very low certainty

1 study

HM17321 increases lean mass in mice (up to +7.9%).
Animalsin SAMP8 mice vs vehicle4 monthsmales
HM17321, a CRFR2 Selective UCN2 Analog, Prevents Muscle Loss and Functional Decline in Sarcopenic Mice · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Latest

1

ADA Scientific Sessions 2026 AbstractAnimals5 Jun

HM17321, a CRFR2 Selective UCN2 Analog, Prevents Muscle Loss and Functional Decline in Sarcopenic Mice