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High ldl cholesterol

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 5 countries
  • In silico1

Outcomes

2

Cardiovascular disease burden

upin humans1

1 study

  1. High ldl cholesterol increases cardiovascular disease burden in humans (DALYs 3M to 5M; YLDs 99,898 to 233,786).

    “DALYs rose from 3 million (2-4 million) to 5 million (3.3-6.7 million), and YLDs increased from 99,898 (52,262-151,746) to 233,786 (123,006-357,585)”

    Humansin Latin America and Caribbean from 1990 to 2021

    SAT-246 Global Burden and Trend of Cardiovascular Disease Attributable to High LDL Cholesterol in Latin America and Caribbean from 1990-2021: An insight from the Global Burden of Disease Study 2021.

    ENDO 2025 abstract22 Oct 2025

Cardiovascular disease mortality

upin humans1

1 study

  1. High ldl cholesterol increases cardiovascular disease mortality in humans (from 115,688 to 207,027 deaths).

    “Between 1990 and 2021, deaths due to CVD attributable to high LDL cholesterol increased from 115,688 (95% uncertainty interval: 69,810-162,451) to 207,027 (127,246-291,152)”

    Humansin Latin America and Caribbean from 1990 to 2021

    SAT-246 Global Burden and Trend of Cardiovascular Disease Attributable to High LDL Cholesterol in Latin America and Caribbean from 1990-2021: An insight from the Global Burden of Disease Study 2021.

    ENDO 2025 abstract22 Oct 2025

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