High-glycemic diet

1. High-glycemic diet impairs microbiome composition in mice.

   “Gut microbiome analysis revealed a pronounced expansion of Proteobacteria and a near-complete loss of Bacteroidota and Firmicutes commensal bacteria in HGAbx”

   Animalswith antibiotics (ampicillin and neomycin)11 months

   Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·10 Dec 2024

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1. High-glycemic diet decreases survival in mice.

   “We observed a significant decrease in survival of mice fed a HG diet containing antibiotics (HGAbx) relative to those fed a LG diet containing antibiotics (LGAbx).”

   Animalswith antibiotics (ampicillin and neomycin)11 months

   Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·10 Dec 2024

1. High-glycemic diet increases Lachnospiraceae abundance in mice.

   “notably, several members of the Lachnospiraceae family increased with aging and HG diet”

   Animalsfecesmales

   Aging Modulates the Effect of Dietary Glycemic Index on Gut Microbiota Composition in Mice

   The Journal of nutrition·15 Jul 2024

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1. High-glycemic diet raises the risk of colonic hyperplasia in mice.

   “HGAbx mice died with an enlarged and hemorrhagic cecum, which is associated with colonic hyperplasia and goblet cell depletion.”

   Animalswith antibiotics (ampicillin and neomycin)11 months

   Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·10 Dec 2024

More on Colonic hyperplasia