High-altitude exposure

1. High-altitude exposure impairs taste sensitivity in humans.

   “high-altitude exposure may moderately reduce taste sensitivity, particularly for sweet stimuli, requiring higher concentrations for correct identification.”

   Human trialn = 17

   Differential response of taste perception to high-altitude exposure and ageing

   Appetite·Dec 8, 2025

1. High-altitude exposure decreases Akkermansia muciniphila abundance in humans (by 10 years).

   “high-altitude plateau environment may accelerate the decline of A. muciniphila by 10 years”

   Humansgut

   High-Altitude Impacts on Gut Microbiota: Accelerated Aging and the Urgency for Targeted Health Interventions

   High altitude medicine & biology·Jul 7, 2025

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1. High-altitude exposure increases Firmicutes to Bacteroidetes ratio in humans.

   “evidenced by reduced diversity and an elevated Firmicutes to Bacteroidetes (F/B) ratio in older subjects”

   Humansgut

   High-Altitude Impacts on Gut Microbiota: Accelerated Aging and the Urgency for Targeted Health Interventions

   High altitude medicine & biology·Jul 7, 2025

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1. High-altitude exposure decreases gut microbiota diversity in humans.

   “evidenced by reduced diversity and an elevated Firmicutes to Bacteroidetes (F/B) ratio in older subjects”

   Humansgut

   High-Altitude Impacts on Gut Microbiota: Accelerated Aging and the Urgency for Targeted Health Interventions

   High altitude medicine & biology·Jul 7, 2025

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1. High-altitude exposure increases PhenoAge in humans (β, 2.08 years; 95% CI, 1.77-2.39 years).

   “The PhenoAge results were similar, with even larger effect sizes (WCNPCS, β, 2.08 years; 95% CI, 1.77-2.39 years”

   Humansn = 9,846

   Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes

   JAMA network open·May 1, 2025

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1. High-altitude exposure increases KDM biological age acceleration in humans (+0.85 years).

   “The participants living at high altitudes presented increased KDM-BA acceleration by 0.85 years for the WCNPCS cohort”

   Humansn = 9,846

   Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes

   JAMA network open·May 1, 2025

More on KDM biological age acceleration

1. High-altitude exposure is associated with biological-age acceleration in humans.

   “The association between high-altitude exposure and biologically accelerated aging was particularly pronounced among smokers.”

   Humansamong smokers

   Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes

   JAMA network open·May 1, 2025

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