Hif-1α-targeting autophagy-tethering compound

1. Hif-1α-targeting autophagy-tethering compound extends lifespan in mice (~14% median lifespan; ~12% maximum lifespan).

   “significantly extended both median (~14%) and maximum lifespan (~12%)”

   Animalssystemic weekly administration

   Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan

   Nature aging·12 May 2026

1. Hif-1α-targeting autophagy-tethering compound decreases age-related pathologies in mice.

   “HATC reduced HIF-1α levels across multiple organs, ameliorated a range of age-related pathologies”

   Animalssystemic weekly administration

   Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan

   Nature aging·12 May 2026

1. Hif-1α-targeting autophagy-tethering compound decreases HIF-1α in mice.

   “In aged mice, systemic weekly administration of HATC reduced HIF-1α levels across multiple organs”

   Animalssystemic weekly administrationmultiple organs

   Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan

   Nature aging·12 May 2026

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