Heat shock

1. Heat shock activates AMPK signalling in worms.

   “HS also activated AMPK and aak-2 was required for hormetic protection”

   Model organisms

   Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways · bioRxiv · 3 Sep 2026 · Preprint

AMPK signalling →

1. Heat shock inhibits mTOR signalling in worms.

   “HS inhibited mTORC1 and dephosphorylated its conserved HLH-30 S201 target site”

   Model organisms

   Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways · bioRxiv · 3 Sep 2026 · Preprint

mTOR signalling →

1. Heat shock extends lifespan in worms.

   “a brief, sublethal heat shock (HS) induces a hormetic response that increases resistance to subsequent stress and extends lifespan.”

   Reviewbrief, sublethal

   Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways · bioRxiv · 3 Sep 2026 · Preprint