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GS-442172

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Gilead Sciences
  • Animals1

Outcomes

3

Hyperpermeability

downin mouse cells1

1 study

  1. GS-442172 decreases hyperpermeability in mouse cells.

    “inhibition of ASK-1 activation improved hyperpermeability in glomerular endothelial cells.”

    Cells

    ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice

    Scientific reports2 Nov 2024

Kidney fibrosis

downin mice1

1 study

  1. GS-442172 decreases kidney fibrosis in mice.

    “ASK-1 inhibition significantly reduced glomerular injury and albuminuria, while also attenuating tubular damage and interstitial fibrosis.”

    Animalsin diabetic kidney disease model mice

    ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice

    Scientific reports2 Nov 2024

Albuminuria

downin mice1

1 study

  1. GS-442172 decreases albuminuria in mice.

    “ASK-1 inhibition significantly reduced glomerular injury and albuminuria, while also attenuating tubular damage and interstitial fibrosis.”

    Animalsin diabetic kidney disease model mice

    ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice

    Scientific reports2 Nov 2024

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