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Granzyme k-high cd8+ t cell co-culture

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Deutsche Forschungsgemeinschaft
  • Animals1

Outcomes

1

Epithelial progenitor function

downin mouse cells1

1 study

  1. Granzyme k-high cd8+ t cell co-culture impairs epithelial progenitor function in mouse cells.

    “its co-culture or Gzmk treatments in lung organoids impaired progenitor function by inducing stem cell senescence.”

    Cellsco-culture with Granzyme K-high CD8+ T cellslung organoids

    Single cell decomposition of multicellular aging programs associated with impaired lung regeneration

    bioRxiv (Cold Spring Harbor Laboratory)28 Jul 2025Preprint

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