Glycyrrhizin
Intervention1 paper5 findingsPubChem 14982ChEBI 15939
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Funder: Japan Society for the Promotion of Science5 of 5 findings with company ties
- Animals1
Outcomes
5cGAS–STING signalling
downin mice1
1 study
cGAS–STING signalling
downin mice1
Glycyrrhizin inhibits cGAS–STING signalling in mice.
Animalsin senescence-accelerated mouse prone 8 (SAMP8; P8) mice12 weeksmales
Glycyrrhizin Ameliorates Learning and Memory Impairment via Inhibition of Neuroinflammation in an Alzheimer's Disease Mouse Model SAMP8 · International journal of molecular sciences · 19 Aug 2026
Inflammation
downin mice1
1 study
Inflammation
downin mice1
Glycyrrhizin decreases inflammation in mice.
Animalsin senescence-accelerated mouse prone 8 (SAMP8; P8) mice12 weeksmales
Glycyrrhizin Ameliorates Learning and Memory Impairment via Inhibition of Neuroinflammation in an Alzheimer's Disease Mouse Model SAMP8 · International journal of molecular sciences · 19 Aug 2026
Phosphorylated tau
downin mice1
1 study
Phosphorylated tau
downin mice1
Glycyrrhizin decreases phosphorylated tau in mice.
Animalsin senescence-accelerated mouse prone 8 (SAMP8; P8) micehippocampus12 weeksmales
Glycyrrhizin Ameliorates Learning and Memory Impairment via Inhibition of Neuroinflammation in an Alzheimer's Disease Mouse Model SAMP8 · International journal of molecular sciences · 19 Aug 2026
Amyloid-beta
downin mice1
1 study
Amyloid-beta
downin mice1
Glycyrrhizin decreases amyloid-beta in mice.
Animalsin senescence-accelerated mouse prone 8 (SAMP8; P8) micehippocampus12 weeksmales
Glycyrrhizin Ameliorates Learning and Memory Impairment via Inhibition of Neuroinflammation in an Alzheimer's Disease Mouse Model SAMP8 · International journal of molecular sciences · 19 Aug 2026
Memory
upin mice1
1 study
Memory
upin mice1
Glycyrrhizin improves memory in mice.
Animalsin senescence-accelerated mouse prone 8 (SAMP8; P8) mice12 weeksmales
Glycyrrhizin Ameliorates Learning and Memory Impairment via Inhibition of Neuroinflammation in an Alzheimer's Disease Mouse Model SAMP8 · International journal of molecular sciences · 19 Aug 2026