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Putrescine + glycine + methionine + threonine

Intervention

1 paper5 findings

PubChemPubChemPubChemPubChemChEBIChEBIChEBIChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Agencia Estatal de Investigación and 7 more
  • Animals1

Outcomes

5

Short-term and long-term memory performance

upin mice1

1 study

  1. Putrescine + glycine + methionine + threonine improves short-term and long-term memory performance in mice.

    “were accompanied by improvements in both short-term and long-term memory performance.”

    Animalswild-type micefour-compound cocktailsingle injection

    Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice

    Aging cell8 Oct 2024

GRIN2B

upin mice1

1 study

  1. Putrescine + glycine + methionine + threonine increases GRIN2B in mice.

    “Finally, the increases in the survival of newly generated neurons and the levels of the NMDA receptor subunit GluN2B”

    Animalswild-type micefour-compound cocktaildentate gyrussingle injection

    Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice

    Aging cell8 Oct 2024

More on GRIN2B

Survival of newly generated neurons

upin mice1

1 study

  1. Putrescine + glycine + methionine + threonine increases survival of newly generated neurons in mice.

    “Finally, the increases in the survival of newly generated neurons and the levels of the NMDA receptor subunit GluN2B”

    Animalswild-type micefour-compound cocktaildentate gyrussingle injection

    Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice

    Aging cell8 Oct 2024

SOX2

upin mice1

1 study

  1. Putrescine + glycine + methionine + threonine increases SOX2 in mice.

    “These changes include increased expression of the Sox2 protein.”

    Animalswild-type micefour-compound cocktaildentate gyrussingle injection

    Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice

    Aging cell8 Oct 2024

More on SOX2

Age-associated epigenetic alterations

downin mice1

1 study

  1. Putrescine + glycine + methionine + threonine decreases age-associated epigenetic alterations in mice.

    “A single injection of the cocktail containing four compounds (putrescine, glycine, methionine and threonine) partially reversed brain aging phenotypes and epigenetic alterations in age-associated genes.”

    Animalswild-type micefour-compound cocktaildentate gyrussingle injection

    Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice

    Aging cell8 Oct 2024

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