GLS1 inhibitor

1 paper4 findings

PubChem 100951644

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Cells1

Outcomes

4

SCX

upin human cells1

1 study

GLS1 inhibitor increases SCX in human cells.
“The mRNA expression of the tendon markers, type 1 collagen, Mohawk and SCX were increased by the GLS1 inhibitor.”
Cellsrotator cuff-derived cells48 h
Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients
BMC musculoskeletal disorders8 Oct 2025

IL-6

downin human cells1

1 study

GLS1 inhibitor decreases IL-6 in human cells.
“The mRNA expression levels of GLS1, IL-6, p16 and p21 were decreased by the GLS1 inhibitor.”
Cellsrotator cuff-derived cells48 h
Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients
BMC musculoskeletal disorders8 Oct 2025

CDKN2A

downin human cells1

1 study

GLS1 inhibitor decreases CDKN2A in human cells.
“The mRNA expression levels of GLS1, IL-6, p16 and p21 were decreased by the GLS1 inhibitor.”
Cellsrotator cuff-derived cells48 h
Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients
BMC musculoskeletal disorders8 Oct 2025

Cell viability

upin human cells1

1 study

GLS1 inhibitor increases cell viability in human cells.
“Cell viability was significantly decreased by IL-1β loading and increased by the GLS1 inhibitor.”
Cellsrotator cuff-derived cells48 h
Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients
BMC musculoskeletal disorders8 Oct 2025

Latest

1 in 12 months

Nature Communications25 Nov

Directed rescue strategy for enhanced implant osteointegration in aged rats

Experiments in ratsInterventions

BMC Musculoskeletal Disorders9 Oct

Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients

Experiments in human cellsInterventions