Germ cell removal
1 paper5 findings
- 1 lab in 1 country
- Funders: Daiichi Sankyo Europe and 3 more
- Animals1
Outcomes
5Body size
upin killifish1
1 study
Body size
upin killifish1
Germ cell removal increases body size in killifish.
“Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively.”
Animals
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
Science advances12 Jun 2024
Vitamin D receptor signalling
upin killifish1
1 study
Vitamin D receptor signalling
upin killifish1
Germ cell removal activates vitamin D receptor signalling in killifish.
“In contrast, germ cell removal in males improved their health with increased vitamin D signaling.”
Animalsmales
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
Science advances12 Jun 2024
Insulin/IGF-1 signalling
upin killifish1
1 study
Insulin/IGF-1 signalling
upin killifish1
Germ cell removal activates insulin/IGF-1 signalling in killifish.
“In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling.”
Animalsfemales
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
Science advances12 Jun 2024
Estrogens
downin killifish1
1 study
Estrogens
downin killifish1
Germ cell removal decreases estrogens in killifish.
“In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling.”
Animalsfemales
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
Science advances12 Jun 2024
Lifespan
downin killifish1
1 study
Lifespan
downin killifish1
Germ cell removal shortens lifespan in killifish.
“In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling.”
Animalsfemales
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
Science advances12 Jun 2024