Generalized seizures

1. Generalized seizures increase CDKN1A in mice.

   “revealed elevated immune-related transcripts (Defb1, Pglyrp1, Bdkrb2) and cell cycle/growth regulators (Cdkn1a, PAX7) in late middle-age mice two months after GS compared to young-adults.”

   Animalstwo months after generalized seizures vs young-adults

   Neurophysiological and neuroinflammatory adaptations to seizure activity in aging

   Neurobiology of disease·4 Nov 2025

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1. Generalized seizures increase inflammation in mice.

   “The late middle-age group exhibited more pronounced increases over time in hippocampal and cortical GFAP+ density and IBA1+ cell number following GS.”

   Animalstwo months after generalized seizures

   Neurophysiological and neuroinflammatory adaptations to seizure activity in aging

   Neurobiology of disease·4 Nov 2025

More on Inflammation

1. Generalized seizures induce seizures in mice.

   “In contrast, in late middle-age mice, GS were sufficient to promote spontaneous case-specific seizures over time, together with SWDs.”

   Animalstwo months after generalized seizures

   Neurophysiological and neuroinflammatory adaptations to seizure activity in aging

   Neurobiology of disease·4 Nov 2025

More on Seizures