Fragaria
Fragaria has been studied in 2 papers since 2017: 1 trial in people, 1 in animals. The newest paper, Oct 19, 2023: “Early Intervention in Cognitive Aging with Strawberry Supplementation”.
“However, the strawberry-treated group exhibited a relative reduction of interference in verbal learning and memory F(1,27) = 5.69, p = 0.02, Cohen’s f = 0.45.”
None of its findings points the other way.
- 2 independent labs in 3 countries
- Funders: California Strawberry Commission and 1 more
- Human trial1
- Animals1
Studies in people
1 study gave fragaria to people and measured what changed.
down: Decreases memory interferenceCohen's f = 0.45
down: Decreases depressive symptomsCohen's f = 0.39
Trial34 people5 males and 25 females50 to 65 years old12 weeks
Overweight, middle-aged men and women with complaints of mild cognitive decline
Nutrients, Oct 19, 2023
What did studies of Fragaria find?
7Studies of Fragaria measured 7 outcomes; the most studied are metabolism (1 study), memory interference (1) and depressive symptoms (1).
metabolism
no changein humans1
1 study
metabolism
no changein humans1
Fragaria has no effect on metabolism in humans.
“With respect to metabolic measures, there was no intervention effect for fasting glucose, p = 0.61, fasting insulin, p = 0.29, HOMA2- IR, p = 0.45, glycated hemoglobin, p = 0.67, or the TG/HDL ratio, p = 0.85, p = 0.43.”
Human trial12 weeksn = 34
Early Intervention in Cognitive Aging with Strawberry Supplementation
Nutrients
Fragaria has no effect on metabolism in humans.
“there was no effect of the intervention on metabolic measures”
Human trialoverweight with insulin resistance and subjective cognitive declinewhole-fruit strawberry powder12 weeks
Early Intervention in Cognitive Aging with Strawberry Supplementation
Nutrients
Memory interference
downin humans1
1 study
Memory interference
downin humans1
Fragaria decreases memory interference in humans (Cohen's f = 0.45).
“However, the strawberry-treated group exhibited a relative reduction of interference in verbal learning and memory F(1,27) = 5.69, p = 0.02, Cohen’s f = 0.45.”
Human trial12 weeksn = 34
Early Intervention in Cognitive Aging with Strawberry Supplementation
Nutrients
Fragaria decreases memory interference in humans (p = 0.02; Cohen's f = 0.45).
“We observed diminished memory interference (p = 0.02; Cohen's f = 0.45)”
Human trialoverweight with insulin resistance and subjective cognitive declinewhole-fruit strawberry powder12 weeks
Early Intervention in Cognitive Aging with Strawberry Supplementation
Nutrients
Depressive symptoms
downin humans1
1 study
Depressive symptoms
downin humans1
Fragaria decreases depressive symptoms in humans (Cohen's f = 0.39).
“In addition, the strawberry group reported lower mood disturbance relative to the placebo group, F(1, 27) = 4.28, p = 0.04, Cohen’s f = 0.39.”
Human trial12 weeksn = 34
Early Intervention in Cognitive Aging with Strawberry Supplementation
Nutrients
Depressive symptoms
downin humans1
1 study
Depressive symptoms
downin humans1
Fragaria decreases depressive symptoms in humans (p = 0.04; Cohen's f = 0.39).
“a reduction of depressive symptoms (p = 0.04; Cohen's f = 0.39) for the strawberry-treated participants”
Human trialoverweight with insulin resistance and subjective cognitive declinewhole-fruit strawberry powder12 weeks
Early Intervention in Cognitive Aging with Strawberry Supplementation
Nutrients
AMPK signaling
upin rats1
1 study
AMPK signaling
upin rats1
Fragaria activates AMPK signaling in rats (P<0.05).
“significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake”
Animals8weeks
Food chemistry
Oxidative stress and ROS signaling
downin rats1
1 study
Oxidative stress and ROS signaling
downin rats1
Fragaria decreases oxidative stress and ROS signaling in rats (P<0.05).
“decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05)”
Animals8weeks
Food chemistry
Mitochondrial biogenesis (PGC-1α)
upin rats1
1 study
Mitochondrial biogenesis (PGC-1α)
upin rats1
Fragaria increases mitochondrial biogenesis (PGC-1α) in rats (P<0.05).
“Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality”
Animals8weeks
Food chemistry