Formoterol

1. Formoterol increases SIRT1 in mice.

   “expression of sirtuin 1 (SIRT1) in aorta is decreased in EPO-induced AAA but remarkably elevated by medium-dose formoterol.”

   Animalsin aorta of EPO-induced AAA micemedium-dose

   Medium-Dose Formoterol Attenuated Abdominal Aortic Aneurysm Induced by EPO via β2AR/cAMP/SIRT1 Pathway

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Feb 14, 2024

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1. Formoterol decreases cellular senescence in mice.

   “senescence of vascular smooth muscle cell (VSMC) is increased by EPO while decreased by medium-dose formoterol both in vivo and in vitro”

   Animalsin EPO-treated VSMCs in vivo and in vitromedium-dose

   Medium-Dose Formoterol Attenuated Abdominal Aortic Aneurysm Induced by EPO via β2AR/cAMP/SIRT1 Pathway

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Feb 14, 2024

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1. Formoterol lowers the risk of abdominal aortic aneurysm in mice (10% vs 55%).

   “The incidence of AAA is 0, 55%, 35%,10%, and 55% in these 5 groups, respectively.”

   Animalsin ApoE-/- mice treated with EPOmedium-dose

   Medium-Dose Formoterol Attenuated Abdominal Aortic Aneurysm Induced by EPO via β2AR/cAMP/SIRT1 Pathway

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Feb 14, 2024

More on Abdominal aortic aneurysm