Formononetin

3 papers9 findings

PubChem 5280378 ChEBI 18088 MeSH C007768

Formononetin extends lifespan in a worm study and reduces neuronal damage and improves cognition in SAMP8 mice. In senescent human fibroblasts, it decreases TP53 and increases FOS. Five findings span two independent labs in two countries; South Korea’s Ministry of Science and ICT funds two findings.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 2 countries

Funders: Science and Technology Department of Zhejiang Province and 1 more

Animals2
Cells1

Outcomes

Lifespan

upin worms1

1 study

Formononetin extends lifespan in worms.
Model organismsunder normal, thermal stress, and oxidative stress conditions37.30 μmol/L
Formononetin improved healthspan via the P53/P21/CDK4 pathway in SAMP8 mice and DAF-16/SKN-1 signaling pathway in C.elegans
Frontiers in pharmacology23 Sep 2026

Neuronal damage

downin mice1

1 study

Formononetin decreases neuronal damage in mice.
Animalsin SAMP8 micehippocampal CA1, DG and cerebral cortex
Formononetin improved healthspan via the P53/P21/CDK4 pathway in SAMP8 mice and DAF-16/SKN-1 signaling pathway in C.elegans
Frontiers in pharmacology23 Sep 2026

Cognitive function

upin mice1

1 study

Formononetin improves cognitive function in mice.
Animalsin SAMP8 mice4, 8, 16 mg/kg5 months
Formononetin improved healthspan via the P53/P21/CDK4 pathway in SAMP8 mice and DAF-16/SKN-1 signaling pathway in C.elegans
Frontiers in pharmacology23 Sep 2026

FOS

upin human cells1

1 study

Formononetin increases FOS in human cells.
Cellsin senescent fibroblasts
Formononetin attenuates cellular senescence through a FOS-mediated mechanism
Biogerontology24 Aug 2026

Latest

3 in 12 months

Frontiers in Pharmacology8 Oct

Formononetin improved healthspan via the P53/P21/CDK4 pathway in SAMP8 mice and DAF-16/SKN-1 signaling pathway in C.elegans

Experiments in miceInterventions

Paper

Biogerontology24 Aug

Formononetin attenuates cellular senescence through a FOS-mediated mechanism

Experiments in human cellsInterventions

Paper

The International Journal of Biochemistry & Cell Biology12 Aug

Formononetin mitigates age-related sarcopenia by blocking mitochondrial ferroptosis via SIRT1/PGC-1α signaling

Experiments in miceSarcopenia

Paper

Formononetin

Outcomes

Latest

Formononetin improved healthspan via the P53/P21/CDK4 pathway in SAMP8 mice and DAF-16/SKN-1 signaling pathway in C.elegans

Formononetin attenuates cellular senescence through a FOS-mediated mechanism

Formononetin mitigates age-related sarcopenia by blocking mitochondrial ferroptosis via SIRT1/PGC-1α signaling

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