Flutamide

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: National Institute on Aging

Animals2

Outcomes

Feminized microglial phenotype

upin rats1

1 study

Flutamide induces feminized microglial phenotype in rats.
“Flutamide had more moderate effects on microglia morphology in males, contributing to a more "feminized" phenotype in the hippocampus in adult and aged males.”
Animalsearly life treatmenthippocampusP0-P1males
Sex differences in microglia morphology and function across the lifespan are mediated by the early hormone environment
Brain, behavior, and immunity19 Nov 2025

Abdominal adiposity

downin mice1

1 study

Flutamide decreases abdominal adiposity in mice.
“Reduction in abdominal adiposity was greater in flutamide-treated mice.”
Animalsfollicle-stimulating hormone receptor haploinsufficiencyadipose tissuefemales
Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice
Reproductive sciences (Thousand Oaks, Calif.)20 Mar 2009

Androgen receptor protein

downin mice1

1 study

Flutamide decreases androgen receptor protein in mice.
“Both compounds significantly downregulated the expression of ovarian androgen receptor protein”
Animalsfollicle-stimulating hormone receptor haploinsufficiencyovaryfemales
Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice
Reproductive sciences (Thousand Oaks, Calif.)20 Mar 2009