FLAV-27

1. FLAV-27 decreases ferroptosis.

   “Multi-omics analyses reveal a global reprogramming of H3K9me2/H3K18me-mediated repression, reduced ferroptosis vulnerabilities”

   Animalspreclinical AD models

   First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease

   Molecular therapy : the journal of the American Society of Gene Therapy·24 Dec 2025

More on Ferroptosis

1. FLAV-27 improves memory performance in mice.

   “In mouse models of both late-onset AD (SAMP8) and early-onset AD (5xFAD), FLAV-27 rescues memory performance, social behavior, and synaptic structure.”

   AnimalsSAMP8 and 5xFAD modelsbrain

   First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease

   Molecular therapy : the journal of the American Society of Gene Therapy·24 Dec 2025

1. FLAV-27 extends lifespan in worms.

   “In Caenorhabditis elegans, it improves mobility, lifespan, and mitochondrial respiration.”

   Model organismspreclinical AD models

   First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease

   Molecular therapy : the journal of the American Society of Gene Therapy·24 Dec 2025