Flagellin-containing fusion protein

Intervention

1 paper5 findings

  • 1 lab in 1 country
  • Funders: Chonnam National University and others
  • Animals1

Outcomes

5

Cellular homeostasis

upin mice1

1 study
  1. Flagellin-containing fusion protein improves cellular homeostasis in mice.

    “Additionally, this fusion protein boosts intestinal mucosal integrity by augmenting the surface expression of TLR5 in a certain subset of dendritic cells and increasing interleukin-22 (IL-22) secretion.”

    Animalsintestine

    Mucosal TLR5 activation controls healthspan and longevity

    Nature communications2 Jan 2024

More on Cellular homeostasis

Pulmonary fibrosis

downin mice1

1 study
  1. Flagellin-containing fusion protein prevents pulmonary fibrosis in mice.

    “prevention of pulmonary lung fibrosis”

    Animalslung

    Mucosal TLR5 activation controls healthspan and longevity

    Nature communications2 Jan 2024

More on Pulmonary fibrosis

Cognitive function

upin mice1

1 study
  1. Flagellin-containing fusion protein improves cognitive function in mice.

    “heightened cognitive capacity”

    Animals

    Mucosal TLR5 activation controls healthspan and longevity

    Nature communications2 Jan 2024

Healthspan

upin mice1

1 study
  1. Flagellin-containing fusion protein improves healthspan in mice.

    “stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin-containing fusion protein effectively extends the lifespan and enhances the healthspan of mice of both sexes.”

    Animals

    Mucosal TLR5 activation controls healthspan and longevity

    Nature communications2 Jan 2024

Lifespan

upin mice1

1 study
  1. Flagellin-containing fusion protein extends lifespan in mice.

    “stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin-containing fusion protein effectively extends the lifespan and enhances the healthspan of mice of both sexes.”

    Animals

    Mucosal TLR5 activation controls healthspan and longevity

    Nature communications2 Jan 2024

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