Flagellin-containing fusion protein
1 paper5 findings
- 1 lab in 1 country
- Funders: Chonnam National University and others
- Animals1
Outcomes
5Cellular homeostasis
upin mice1
1 study
Cellular homeostasis
upin mice1
Flagellin-containing fusion protein improves cellular homeostasis in mice.
“Additionally, this fusion protein boosts intestinal mucosal integrity by augmenting the surface expression of TLR5 in a certain subset of dendritic cells and increasing interleukin-22 (IL-22) secretion.”
Animalsintestine
Mucosal TLR5 activation controls healthspan and longevity
Nature communications2 Jan 2024
Pulmonary fibrosis
downin mice1
1 study
Pulmonary fibrosis
downin mice1
Flagellin-containing fusion protein prevents pulmonary fibrosis in mice.
“prevention of pulmonary lung fibrosis”
Animalslung
Mucosal TLR5 activation controls healthspan and longevity
Nature communications2 Jan 2024
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
Flagellin-containing fusion protein improves cognitive function in mice.
“heightened cognitive capacity”
Animals
Mucosal TLR5 activation controls healthspan and longevity
Nature communications2 Jan 2024
Healthspan
upin mice1
1 study
Healthspan
upin mice1
Flagellin-containing fusion protein improves healthspan in mice.
“stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin-containing fusion protein effectively extends the lifespan and enhances the healthspan of mice of both sexes.”
Animals
Mucosal TLR5 activation controls healthspan and longevity
Nature communications2 Jan 2024
Lifespan
upin mice1
1 study
Lifespan
upin mice1
Flagellin-containing fusion protein extends lifespan in mice.
“stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin-containing fusion protein effectively extends the lifespan and enhances the healthspan of mice of both sexes.”
Animals
Mucosal TLR5 activation controls healthspan and longevity
Nature communications2 Jan 2024