FAT-1 gene therapy

1. FAT-1 gene therapy decreases joint degeneration in mice.

   “decreasing the serum ω-6:ω-3 FA ratio had a strong senomorphic and therapeutic effect, mitigating metabolic dysfunction, cellular senescence, and joint degeneration.”

   AnimalsMice fed an omega-6-rich high-fat diet and subjected to destabilization of the medial meniscusAAV8-fat1joint

   Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis

   Proceedings of the National Academy of Sciences of the United States of America·14 Oct 2024

1. FAT-1 gene therapy decreases cellular senescence in mice.

   “decreasing the serum ω-6:ω-3 FA ratio had a strong senomorphic and therapeutic effect, mitigating metabolic dysfunction, cellular senescence, and joint degeneration.”

   AnimalsMice fed an omega-6-rich high-fat diet and subjected to destabilization of the medial meniscusAAV8-fat1

   Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis

   Proceedings of the National Academy of Sciences of the United States of America·14 Oct 2024

More on Cellular senescence

1. FAT-1 gene therapy decreases metabolic dysfunction in mice.

   “decreasing the serum ω-6:ω-3 FA ratio had a strong senomorphic and therapeutic effect, mitigating metabolic dysfunction, cellular senescence, and joint degeneration.”

   AnimalsMice fed an omega-6-rich high-fat diet and subjected to destabilization of the medial meniscusAAV8-fat1

   Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis

   Proceedings of the National Academy of Sciences of the United States of America·14 Oct 2024

More on Metabolic dysfunction