Extracorporeal liver cross-circulation

1. Extracorporeal liver cross-circulation increases VWF in pigs.

   “Human platelets colocalized with activated porcine endothelial cells, which showed increasing porcine vWF expression over time”

   Human trialin activated endothelial cells over timeendothelial cell

   Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents

   Nature medicine·7 Jul 2026

More on VWF

1. Extracorporeal liver cross-circulation induces immune cell in humans.

   “Spatial transcriptomic analysis revealed progressive infiltration of human immune cells (predominantly inflammatory macrophages and neutrophils) in the xenografts”

   Human trialin porcine liver xenograftsliver

   Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents

   Nature medicine·7 Jul 2026

1. Extracorporeal liver cross-circulation raises the risk of thrombocytopenia in humans.

   “We previously performed five ELC procedures in four brain-dead human decedents, during which the recipients developed severe thrombocytopenia.”

   Reviewduring five ELC procedures in four brain-dead human decedentsn = 4

   Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents

   Nature medicine·7 Jul 2026

More on Thrombocytopenia