Nicotinamide riboside + exercise

1. Nicotinamide riboside + exercise increases peak VO2 in humans (0.21 L/min, 95% CI 0.05 to 0.36, padjusted=0.0299).

   “0·21 (0·05 to 0·36; padjusted=0·0299) for nicotinamide riboside and exercise in combination”

   Human trialFriedreich's ataxia12 weeksn = 66

   Safety and efficacy of individualised exercise and NAD⁺ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial

   The Lancet. Neurology·17 Apr 2026

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1. Nicotinamide riboside + exercise has no effect on daytime systolic blood pressure in humans (5.19 ± 13.2 vs - 2.71 ± 10.5 mmHg).

   “NR + Ex (mean change = 5.19 ± 13.2 mmHg) did not reduce SBP more than PL + Ex (- 2.71 ± 10.5 mmHg).”

   Human trialhypertension6 weeksn = 54

   Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial

   GeroScience·7 Aug 2025

More on Daytime systolic blood pressure