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Nicotinamide mononucleotide + exercise

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Science and Technology Council
  • Animals1

Outcomes

2

Aerobic endurance

upin mice1

1 study

  1. Nicotinamide mononucleotide + exercise improves aerobic endurance in mice (p < 0.05).

    “The AENMN group demonstrated significant improvements in maximal strength and aerobic endurance compared with the AS group (p < 0.05).”

    Animalscombined NMN and exercise vs aged sedentary6 weeksmales

    Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice

    Nutrients2 Oct 2025

Maximal strength

upin mice1

1 study

  1. Nicotinamide mononucleotide + exercise improves maximal strength in mice (p < 0.05).

    “The AENMN group demonstrated significant improvements in maximal strength and aerobic endurance compared with the AS group (p < 0.05).”

    Animalscombined NMN and exercise vs aged sedentary6 weeksmales

    Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice

    Nutrients2 Oct 2025

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