Etomoxir
Etomoxir has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Nov 23, 2022: “A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects”.
1 of its findings points the other way.
- 2 independent labs in 2 countries
- 1 finding against
- Funders: National Institute on Aging and 6 more
- Model organisms1
What did studies of Etomoxir find?
2Studies of Etomoxir measured 2 outcomes; the most studied are lifespan (1 study) and cellular senescence (1).
Lifespan
no changein flies1upin flies1
1 study
Lifespan
no changein flies1upin flies1
Etomoxir has no effect on lifespan in flies.
“Etomoxir inhibits lipid metabolism, and significantly increased life span in virgin and mated females, but not males, at 50 μM concentration.”
Model organisms50 μMmales
Fly
Etomoxir extends lifespan in flies.
“Etomoxir inhibits lipid metabolism, and significantly increased life span in virgin and mated females, but not males, at 50 μM concentration.”
Model organismsvirgin and mated50 μMfemales
Fly
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
Etomoxir increases cellular senescence in human cells.
“Impairment of fatty acid metabolism by silencing CPT1A or CPT1A inhibitor etomoxir facilitated the development of endothelial senescence”
Cellssilencing CPT1A or CPT1A inhibitor etomoxir
Oxidative medicine and cellular longevity