Engineered mitochondria
Intervention1 paper4 findings
- Animals1
Outcomes
4Trabecular bone microarchitecture
upin animals1Very low certainty
1 study
Trabecular bone microarchitecture
upin animals1Very low certainty
Engineered mitochondria improves trabecular bone microarchitecture.
Animalsovariectomy induced osteoporosis modeltrabecular bone
Mitochondrial transfer restored bone structure in animals · Advanced Functional Materials · 27 Aug 2026
Vascularization
upin animals1Very low certainty
1 study
Vascularization
upin animals1Very low certainty
Engineered mitochondria increases vascularization.
Animalsovariectomy induced osteoporosis modelbone
Mitochondrial transfer restored bone structure in animals · Advanced Functional Materials · 27 Aug 2026
angiogenic activity
upin cells1Very low certainty
1 study
angiogenic activity
upin cells1Very low certainty
Engineered mitochondria increases angiogenic activity in cells.
Cellsmitochondria derived from BMSCs treated with DEX@LDH/METvascular endothelial cell
Mitochondrial transfer restored bone structure in animals · Advanced Functional Materials · 27 Aug 2026
Vascular endothelial cell proliferation
upin cells1Very low certainty
1 study
Vascular endothelial cell proliferation
upin cells1Very low certainty
Engineered mitochondria increases vascular endothelial cell proliferation in cells.
Cellsmitochondria derived from BMSCs treated with DEX@LDH/METvascular endothelial cell
Mitochondrial transfer restored bone structure in animals · Advanced Functional Materials · 27 Aug 2026
Latest
1Mitochondrial transfer restored bone structure in animals
In an osteoporosis animal model, mitochondria from treated stem cells promoted blood vessel formation and restored the structure of spongy bone.In an osteoporosis animal model, mitochondria from treated stem cells promoted blood vessel formation and restored the structure of spongy bone.