Engineered mesenchymal stem cell-derived exosomes

1. Engineered mesenchymal stem cell-derived exosomes increase clonogenic capacity and cellular viability in cells.

   “Clonogenic capacity and cellular viability were markedly enhanced.”

   Cellsreplicative senescencedual miR-195/miR-188 sponge-loaded exosomesadipose-derived mesenchymal stem cell

   Synergistic reversal of mesenchymal stem cell senescence by engineered exosomal delivery of a dual miR-195/miR-188 sponge

   Experimental gerontology·8 Oct 2026

1. Engineered mesenchymal stem cell-derived exosomes decrease senescence markers in cells.

   “Treatment significantly reduced senescence markers, including p16, p53, NF-κB, IL-6, and RB, while decreasing reactive oxygen species levels and β-galactosidase activity.”

   Cellsreplicative senescencedual miR-195/miR-188 sponge-loaded exosomesadipose-derived mesenchymal stem cell

   Synergistic reversal of mesenchymal stem cell senescence by engineered exosomal delivery of a dual miR-195/miR-188 sponge

   Experimental gerontology·8 Oct 2026

More on Senescence markers

1. Engineered mesenchymal stem cell-derived exosomes decrease intracellular miR-195 and miR-188 in cells.

   “Quantitative RT-PCR analysis confirmed that sponge-loaded exosomes significantly reduced intracellular levels of miR-195 and miR-188, demonstrating effective functional sequestration.”

   Cellsreplicative senescencedual miR-195/miR-188 sponge-loaded exosomesadipose-derived mesenchymal stem cell

   Synergistic reversal of mesenchymal stem cell senescence by engineered exosomal delivery of a dual miR-195/miR-188 sponge

   Experimental gerontology·8 Oct 2026

More on Intracellular miR-195 and miR-188