Engineered fsh
1 paper3 findings
- 1 lab in 1 country
- Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 4 more
- Animals1
Outcomes
3Fertilization competency
upin mice1
1 study
Fertilization competency
upin mice1
Engineered fsh improves fertilization competency in mice.
“rerouted FSH vastly improved the in vivo fertilization competency of eggs”
Animalsovaryfemales
Proceedings of the National Academy of Sciences of the United States of America31 Mar 2014
Lifespan
upin mice1
1 study
Lifespan
upin mice1
Engineered fsh extends lifespan in mice.
“the rerouted FSH enhanced ovarian follicle survival, caused a dramatic increase in number of ovulations, and prolonged female reproductive lifespan.”
Animalsovaryfemales
Proceedings of the National Academy of Sciences of the United States of America31 Mar 2014
Ovarian defects
downin mice1
1 study
Ovarian defects
downin mice1
Engineered fsh decreases ovarian defects in mice.
“FSH released from the LH secretory pathway rescued ovarian defects in Fshb-null mice as efficiently as constitutively secreted FSH.”
Animalsin Fshb-null miceovaryfemales
Proceedings of the National Academy of Sciences of the United States of America31 Mar 2014