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Engineered AAV9-HAP-1-SHRAB27A

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Government of Jiangsu Province and 2 more
  • Animals1

Outcomes

3

Inflammation

downin mice1

1 study

  1. Engineered AAV9-HAP-1-SHRAB27A decreases inflammation in mice.

    “significantly reduced synovial hyperplasia, cartilage degradation and inflammatory responses”

    Animalsdestabilization of the medial meniscus (DMM)

    Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

    Journal of extracellular vesicles1 Sep 2025

More on Inflammation

Cartilage degradation

downin mice1

1 study

  1. Engineered AAV9-HAP-1-SHRAB27A decreases cartilage degradation in mice.

    “significantly reduced synovial hyperplasia, cartilage degradation and inflammatory responses”

    Animalsdestabilization of the medial meniscus (DMM)

    Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

    Journal of extracellular vesicles1 Sep 2025

Synovial hyperplasia

downin mice1

1 study

  1. Engineered AAV9-HAP-1-SHRAB27A decreases synovial hyperplasia in mice.

    “significantly reduced synovial hyperplasia, cartilage degradation and inflammatory responses”

    Animalsdestabilization of the medial meniscus (DMM)

    Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect

    Journal of extracellular vesicles1 Sep 2025

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