Endothelial extracellular vesicles
Endothelial extracellular vesicles has been studied in 2 papers since 2026: 1 observational study in people, 1 in cells; 2 in the past year. The newest paper, Jun 26, 2026: “Endothelial extracellular vesicles preserve vascular smooth muscle cell identity but do not reverse endothelial senescence”.
2 papers study it8 findingsUpdated
- 2 independent labs in 2 countries
- Funders: Agencia Nacional de Investigación y Desarrollo and 3 more
- Humans1
- Cells1
What did studies of Endothelial extracellular vesicles find?
8Studies of Endothelial extracellular vesicles measured 8 outcomes; the most studied are cellular senescence (1 study), NOS3 (1) and cell migration (1).
Cellular senescence
no changein cells1
1 study
Cellular senescence
no changein cells1
Endothelial extracellular vesicles have no effect on cellular senescence in cells.
“failed to reverse inflammatory and mitochondrial features of senescence after short-term exposure”
Cellsafter short-term exposure
npj aging
NOS3
downin cells1
1 study
NOS3
downin cells1
Endothelial extracellular vesicles protect against NOS3 in cells.
“In endothelial cells, EVs protected against TNF-α-induced eNOS downregulation”
CellsTNF-α-induced
npj aging
Cell migration
downin cells1
1 study
Cell migration
downin cells1
Endothelial extracellular vesicles decrease cell migration in cells.
“preserving contractile markers and limiting migration.”
CellsPDGF-BB-induced
npj aging
Vascular smooth muscle cell dedifferentiation
downin cells1
1 study
Vascular smooth muscle cell dedifferentiation
downin cells1
Endothelial extracellular vesicles prevent vascular smooth muscle cell dedifferentiation in cells.
“EVs from non-senescent endothelial cells prevent PDGF-BB-induced VSMC dedifferentiation, preserving contractile markers and limiting migration.”
CellsPDGF-BB-induced
npj aging
Tissue plasminogen activator
downin human cells1
1 study
Tissue plasminogen activator
downin human cells1
Endothelial extracellular vesicles decrease tissue plasminogen activator in human cells (∼30%).
“t-PA release in response to thrombin was significantly lower (∼30%) in hCMECs treated with EEVs from older adults.”
Cellsin response to thrombin, compared to EEVs from young adultscerebral microvascular endothelial cellsn = 30
American journal of physiology. Heart and circulatory physiology
Endothelin-1
upin human cells1
1 study
Endothelin-1
upin human cells1
Endothelial extracellular vesicles increase Endothelin-1 in human cells (27.3 ± 9.1 vs. 21.2 ± 5.5 pg/mL).
“ET-1 production (27.3 ± 9.1 vs. 21.2 ± 5.5 pg/mL; P = 0.03) were significantly higher in hCMECs treated with EEVs from older adults.”
Cellscompared to EEVs from young adultscerebral microvascular endothelial cellsn = 30
American journal of physiology. Heart and circulatory physiology
Nitric oxide
downin human cells1
1 study
Nitric oxide
downin human cells1
Endothelial extracellular vesicles decrease nitric oxide in human cells (5.9 ± 1.6 vs. 7.3 ± 1.3 μmol/L).
“NO production (5.9 ± 1.6 vs. 7.3 ± 1.3 μmol/L) was significantly lower in hCMECs treated with EEVs from older adults.”
Cellscompared to EEVs from young adultscerebral microvascular endothelial cellsn = 30
American journal of physiology. Heart and circulatory physiology
Oxidative stress and ROS signaling
upin human cells1
1 study
Oxidative stress and ROS signaling
upin human cells1
Endothelial extracellular vesicles increase oxidative stress and ROS signaling in human cells (140 ± 51 vs. 99 ± 16% of control).
“EEVs from older adults induced higher reactive oxygen species (ROS; 140 ± 51 vs. 99 ± 16% of control; P = 0.02) production”
Cellscompared to EEVs from young adultscerebral microvascular endothelial cellsn = 30
American journal of physiology. Heart and circulatory physiology