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Empirical dietary index for hyperinsulinemia

Empirical dietary index for hyperinsulinemia has been studied in 4 papers since 2021: 4 observational studies in people; 3 in the past year. The newest story, Nov 4, 2026: “Healthy-diet blood patterns linked to lower odds of eye disease”.

Intervention

4 papers study it7 findingsUpdated

1 new paper in 30 daysSee all 4 papers on empirical dietary index for hyperinsulinemia

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“the reverse EDIH (quintile 5 vs 1) was associated with the largest reduction in weight gain (mean, -0.28 kg/y; 95% CI, -0.30 to -0.26 kg/y)”
Optimal Dietary Patterns for Lower Weight Gain and Risk of Obesity Surrounding MenopauseJAMA network open2026doi:10.1001/jamanetworkopen.2026.13102

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 3 more
  • Humans4

What did studies of empirical dietary index for hyperinsulinemia find?

4

Studies of empirical dietary index for hyperinsulinemia measured 4 outcomes; the most studied are high-density lipoprotein cholesterol (1 study), adiponectin (1) and HOMA-IR (1).

High-density lipoprotein cholesterol

downin humans1

1 study

  1. Empirical dietary index for hyperinsulinemia is linked with lower high-density lipoprotein cholesterol in humans (per 1 SD increment in EDIH score) (-2.4% per 1 SD increment).

    “while reducing high-density lipoprotein cholesterol by 2.4%”

    Humansper 1 SD increment in EDIH scorefemalesn = 35,360

    Proinflammatory and Hyperinsulinemic Dietary Patterns Are Associated With Specific Profiles of Biomarkers Predictive of Chronic Inflammation, Glucose-Insulin Dysregulation, and Dyslipidemia in Postmenopausal Women

    Frontiers in nutrition

More on High-density lipoprotein cholesterol

Adiponectin

downin humans1

1 study

  1. Empirical dietary index for hyperinsulinemia is linked with lower adiponectin in humans (per 1 SD increment in EDIH score) (-2.4% per 1 SD increment).

    “reduced adiponectin by 2.4%”

    Humansper 1 SD increment in EDIH scorefemalesn = 35,360

    Proinflammatory and Hyperinsulinemic Dietary Patterns Are Associated With Specific Profiles of Biomarkers Predictive of Chronic Inflammation, Glucose-Insulin Dysregulation, and Dyslipidemia in Postmenopausal Women

    Frontiers in nutrition

More on Adiponectin

HOMA-IR

upin humans1

1 study

  1. Empirical dietary index for hyperinsulinemia is linked with higher HOMA-IR in humans (per 1 SD increment in EDIH score) (+8% per 1 SD increment).

    “For EDIH, the percent change in biomarker concentration in the insulin-related biomarkers ranged from +1.3% (glucose) to +8% (homeostatic model assessment for insulin resistance)”

    Humansper 1 SD increment in EDIH scorefemalesn = 35,360

    Proinflammatory and Hyperinsulinemic Dietary Patterns Are Associated With Specific Profiles of Biomarkers Predictive of Chronic Inflammation, Glucose-Insulin Dysregulation, and Dyslipidemia in Postmenopausal Women

    Frontiers in nutrition

More on HOMA-IR

C-reactive protein

upin humans1

1 study

  1. Empirical dietary index for hyperinsulinemia is linked with higher C-reactive protein in humans (per 1 SD increment in EDIH score) (+7.8% per 1 SD increment).

    “EDIH impacted inflammation and endothelial dysfunction biomarkers from +1.1% (TNF-αR2) to +7.8% (CRP)”

    Humansper 1 SD increment in EDIH scorefemalesn = 35,360

    Proinflammatory and Hyperinsulinemic Dietary Patterns Are Associated With Specific Profiles of Biomarkers Predictive of Chronic Inflammation, Glucose-Insulin Dysregulation, and Dyslipidemia in Postmenopausal Women

    Frontiers in nutrition

More on C-reactive protein

What is empirical dietary index for hyperinsulinemia linked with?

3

Studies link empirical dietary index for hyperinsulinemia with 3 measures, most often red and processed meats (1 study), incident obesity (1) and annual weight gain (1).

Red and processed meats

upin humans1

1 study

  1. Empirical dietary index for hyperinsulinemia is associated with red and processed meats in humans.

    “EDIH showed the largest positive correlations with red or processed meats, sodium, and French fries.”

    Humansfemalesn = 38,283

    Optimal Dietary Patterns for Lower Weight Gain and Risk of Obesity Surrounding Menopause

    JAMA network open

More on Red and processed meats

Incident obesity

downin humans1HR 0.51

1 study

  1. Empirical dietary index for hyperinsulinemia is associated with incident obesity in humans (reverse-scored) (HR 0.51 (95% CI 0.46 to 0.56)).

    “reverse EDIH (hazard ratio, 0.51; 95% CI, 0.46 to 0.56)”

    Humansreverse-scoredreverse-scoredfemalesn = 38,283

    Optimal Dietary Patterns for Lower Weight Gain and Risk of Obesity Surrounding Menopause

    JAMA network open

More on Incident obesity

Annual weight gain

downin humans1

1 study

  1. Empirical dietary index for hyperinsulinemia is associated with annual weight gain in humans (reverse-scored, quintile 5 vs 1) (mean -0.28 kg/y (95% CI -0.30 to -0.26)).

    “the reverse EDIH (quintile 5 vs 1) was associated with the largest reduction in weight gain (mean, -0.28 kg/y; 95% CI, -0.30 to -0.26 kg/y)”

    Humansreverse-scored, quintile 5 vs 1reverse-scoredfemalesn = 38,283

    Optimal Dietary Patterns for Lower Weight Gain and Risk of Obesity Surrounding Menopause

    JAMA network open

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 1Mar 2026: 0Apr 2026: 0May 2026: 1Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 13 papers in 12 months
Investigative Ophthalmology & Visual Science

Healthy-diet blood patterns linked to lower odds of eye disease

Blood signatures of four healthy diets were linked to 12% to 16% lower odds of age-related macular degeneration per standard-deviation increase.Blood signatures of four healthy diets were linked to 12% to 16% lower odds of age-related macular degeneration per standard-deviation increase.

Cross-sectional · 504 peopleEye
Paper

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