Dual-aav split base editors

1 paper1 finding

1 lab in 1 country

Funders: Howard Hughes Medical Institute and 7 more

Animals1

Outcomes

1

Base editing efficiency

upin mice1+59%

1 study

Dual-aav split base editors increase base editing efficiency in mice (up to 59%).
“Optimized dual AAVs enable in vivo base editing at therapeutically relevant efficiencies and dosages in the mouse brain (up to 59% of unsorted cortical tissue)”
Animalsbrain
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
Nature biomedical engineering14 Jan 2020

Latest

Nature Biomedical Engineering14 Jan

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

Experiments in miceEye