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Nicotinamide mononucleotide + decursin + l-cysteine

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Animals1

Outcomes

4

Epidermal thickness

downin mice1

1 study

  1. Nicotinamide mononucleotide + decursin + l-cysteine decreases epidermal thickness in mice.

    “both, mixture-L and mixture-H treatments reduced epidermal thickness, scratching behavior, and transepidermal water loss”

    Animalsin dinitrochlorobenzene-induced ADskin

    A Mixture of Nicotinamide Mononucleotide, Decursin, and l-Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology

    Journal of medicinal food24 Mar 2025

Scratching behavior

downin mice1

1 study

  1. Nicotinamide mononucleotide + decursin + l-cysteine decreases scratching behavior in mice.

    “both, mixture-L and mixture-H treatments reduced epidermal thickness, scratching behavior, and transepidermal water loss”

    Animalsin dinitrochlorobenzene-induced ADskin

    A Mixture of Nicotinamide Mononucleotide, Decursin, and l-Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology

    Journal of medicinal food24 Mar 2025

Oxidative stress and ROS signalling

downin human cells1

1 study

  1. Nicotinamide mononucleotide + decursin + l-cysteine decreases oxidative stress and ROS signalling in human cells.

    “significantly reduced oxidative stress levels induced by 2,2'-azobis(2-amidinopropane) dihydrochloride”

    Cellsinduced by 2,2'-azobis(2-amidinopropane) dihydrochloridekeratinocytes

    A Mixture of Nicotinamide Mononucleotide, Decursin, and l-Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology

    Journal of medicinal food24 Mar 2025

More on Oxidative stress and ROS signalling

Cellular senescence

downin human cells1

1 study

  1. Nicotinamide mononucleotide + decursin + l-cysteine decreases cellular senescence in human cells.

    “Mixture B further reduced senescence-associated heterochromatin foci formation under oxidative stress”

    Cellsunder 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidative stresskeratinocytes

    A Mixture of Nicotinamide Mononucleotide, Decursin, and l-Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology

    Journal of medicinal food24 Mar 2025

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