Neurobiology of Stress
Cellular senescence as a driver of cognitive decline triggered by chronic unpredictable stress
Experiments in miceInterventions
Papers on dasatinib + quercetin
394 papers8 new in 30 days
Tuesday, June 8
Sunday, May 23
Experimental Gerontology
Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice
Experiments in miceSenolytics
Thursday, April 8
Cell Communication and Signaling
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin
Experiments in miceSenolytics
Saturday, January 30
International Journal of Obesity
Cellular senescence and its role in white adipose tissue
ReviewCellular senescence
Wednesday, January 20
Saturday, January 9
Free Radical Biology & Medicine
Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy
Experiments in animalsInterventions
Thursday, January 7
The Journals of Gerontology, Series A
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
Experiments in miceSenolytics
Wednesday, July 8
Stem Cell Research & Therapy
Cellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mouse offspring
Experiments in miceDexamethasone
Thursday, June 25
Thursday, June 18
International Journal of Molecular Sciences
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics
Experiments in ratsSenolytics
Wednesday, May 27
Stem Cell Research & Therapy
Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA
Experiments in animalsInterventions
Wednesday, May 6
Nature Cell Biology
FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome
Experiments in miceCellular senescence
Tuesday, March 3
Frontiers in Oncology
Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells
Experiments in animalsSenolytics
Thursday, February 6
Journal of Bone and Mineral Research
Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss
Experiments in miceBones and joints
Monday, January 20
Wednesday, September 18
EBioMedicine
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Non-randomized trial in 9 peopleSenolytics
Tuesday, March 12
Aging Cell
Aged-senescent cells contribute to impaired heart regeneration
Experiments in cellsCellular senescence
Saturday, January 5
EBioMedicine
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Non-randomized trial in 14 peopleSenolytics
Friday, December 7
American Journal of Respiratory Cell and Molecular Biology
Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells
Experiments in human cellsCellular senescence
Tuesday, October 30
Frontiers in Oncology
Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer
Experiments in miceSenolytics
Monday, July 9
Nature Medicine
Senolytics improve physical function and increase lifespan in old age
Experiments in miceSenolytics
Wednesday, June 14
Nature Communications
Cellular senescence drives age-dependent hepatic steatosis
Experiments in miceHepatic steatosis
Friday, February 24
Friday, August 5
Wednesday, April 22
Aging Cell
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Experiments in miceSenolytics