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Dapagliflozin + ramipril

Intervention

1 paper5 findings

PubChem 9887712PubChem 5362129ChEBI 85078ChEBI 8774

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 2 more
  • Animals1

Outcomes

5

Tubulointerstitial fibrosis

downin mice1

1 study

  1. Dapagliflozin + ramipril decreases tubulointerstitial fibrosis in mice.

    “The combination therapy better preserves renal function, reduces both lipid accumulation and cell senescence, and decreases glomerulosclerosis and tubulointerstitial fibrosis.”

    Animalsin Col4α3 KO micekidney

    Dapagliflozin, in addition to ramipril, ameliorates kidney disease progression in mice with Alport syndrome

    American journal of physiology. Renal physiology11 Jun 2025

More on Tubulointerstitial fibrosis

Renal function

upin mice1

1 study

  1. Dapagliflozin + ramipril improves renal function in mice.

    “At 15 wk, D/R-treated mice had better renal function and histopathology than those on ramipril alone.”

    Animalsin Col4α3 KO mice

    Dapagliflozin, in addition to ramipril, ameliorates kidney disease progression in mice with Alport syndrome

    American journal of physiology. Renal physiology11 Jun 2025

Lipid and ceramide metabolism

downin mice1

1 study

  1. Dapagliflozin + ramipril decreases lipid and ceramide metabolism in mice.

    “Kidneys from D/R-treated mice exhibited reduced lipid accumulation and cell senescence.”

    Animalsin Col4α3 KO micekidney

    Dapagliflozin, in addition to ramipril, ameliorates kidney disease progression in mice with Alport syndrome

    American journal of physiology. Renal physiology11 Jun 2025

More on Lipid and ceramide metabolism

Cellular senescence

downin mice1

1 study

  1. Dapagliflozin + ramipril decreases cellular senescence in mice.

    “Kidneys from D/R-treated mice exhibited reduced lipid accumulation and cell senescence.”

    Animalsin Col4α3 KO micekidney

    Dapagliflozin, in addition to ramipril, ameliorates kidney disease progression in mice with Alport syndrome

    American journal of physiology. Renal physiology11 Jun 2025

More on Cellular senescence

Lifespan

upin mice1

1 study

  1. Dapagliflozin + ramipril extends lifespan in mice (median 157 vs. 125 days).

    “D/R also extended survival compared with ramipril alone (median 157 vs. 125 days, P < 0.01).”

    Animalsin Col4α3 KO micedrinking water1.5 mg/kg/day + 10 mg/kg/dayuntil death

    Dapagliflozin, in addition to ramipril, ameliorates kidney disease progression in mice with Alport syndrome

    American journal of physiology. Renal physiology11 Jun 2025

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