[d-ala2, D-leu5]-enkephalin

[d-ala2, D-leu5]-enkephalin has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Sep 23, 2024: “Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice”.

Intervention

1 paper studies it1 more mentions it5 findingsUpdated

PubChemChEBI

More peptides

  • 1 lab in 1 country
  • Animals1

What did studies of [d-ala2, D-leu5]-enkephalin find?

5

Studies of [d-ala2, D-leu5]-enkephalin measured 5 outcomes; the most studied are telomere length (1 study), inflammation (1) and physical function (1).

Telomere length

upin mice1

1 study
  1. [d-ala2, D-leu5]-enkephalin increases telomere length in mice.

    “DADLE supplementation significantly prolonged relative telomere length in aged female mice”

    Animalsintraperitoneally injected2 monthsfemales

    Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice

    Molecular neurobiology

More on Telomere length

Inflammation

downin mice1

1 study
  1. [d-ala2, D-leu5]-enkephalin decreases inflammation in mice.

    “DADLE attenuated age-related inflammation, as evidenced by reductions in serum pro-inflammatory cytokines”

    Animalsintraperitoneally injected2 monthsfemales

    Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice

    Molecular neurobiology

More on Inflammation

Physical function

upin mice1

1 study
  1. [d-ala2, D-leu5]-enkephalin improves physical function in mice.

    “improved motor function, enhanced cognitive performance”

    Animalsintraperitoneally injected2 monthsfemales

    Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice

    Molecular neurobiology

Cognitive function

upin mice1

1 study
  1. [d-ala2, D-leu5]-enkephalin improves cognitive function in mice.

    “improved motor function, enhanced cognitive performance”

    Animalsintraperitoneally injected2 monthsfemales

    Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice

    Molecular neurobiology

Lifespan

upin mice1

1 study
  1. [d-ala2, D-leu5]-enkephalin extends lifespan in mice.

    “improved motor function, enhanced cognitive performance and significantly extended lifespan.”

    Animalsintraperitoneally injected2 monthsfemales

    Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice

    Molecular neurobiology

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