2 papers2 findings
Anabolic bone response
upin mice1
Cyclic mechanical loading induces anabolic bone response in mice.
“In aged PolgA mice, the mechanosensitivity of the regenerative response was retained with an anabolic response localized to the defect center.”
AnimalsPolgA D257A/D257A mice with femur defectsbone defect center
bioRxiv (Cold Spring Harbor Laboratory)3 Feb 2026Preprint
Bone regeneration
upin mice1
Cyclic mechanical loading improves bone regeneration in mice.
“Cyclic mechanical loading significantly enhanced the regenerative response in young PolgA mice inducing sustained bone formation, suppressing bone resorption, and enhancing mineralization,”
AnimalsPolgA D257A/D257A mice with femur defectsbone
bioRxiv (Cold Spring Harbor Laboratory)3 Feb 2026Preprint
In a four-week mouse experiment, a bone-building hormone enlarged the spaces housing bone cells, while a drug that slows bone breakdown stabilised their local structure.In a four-week mouse experiment, a bone-building hormone enlarged the spaces housing bone cells, while a drug that slows bone breakdown stabilised their local structure.